Name: Anti-Bax antibody
Price: 224.00 USD

Overview
- Bax is a protein encoded by the BAX gene which is approximately 21, 1 kDa. Bax is localised to the mitochondrion membrane and cytoplasm. It is involved in PEDF induced signalling, apoptosis modulation and signalling and the TNFR1 pathway. This protein falls under the BCL2 protein family. It forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein interacts with, and increases the opening of, the mitochondrial voltage-dependent anion channel, which leads to the loss in membrane potential and the release of cytochrome c. Bax is expressed in a wide variety of tissues. Mutations in the BAX gene may result in colorectal cancer and leukaemia. STJ97725 was developed from clone 6F11 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous Bax protein.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; rat; mouse; chicken
  
  Clone
  
  6F11
  
  Immunogen
  
  synthetic peptide derived from Bax
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Apoptosis Regulator Bax; Bcl-2-Like Protein 4; Bcl2-L-4 (Gene ID:581; UniProt:Q07812)
  
  * For research use only