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Overview
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Akt is a-protein kinase consisting of three proteins (Akt1, Akt2 and Akt3) encoded by the AKT gene which is approximately 55 kDa. Akt is localised to the cytoplasm, nucleus and cell membrane and is involved pathways such as RET signalling, regulation of lipid metabolism, insulin signalling-generic cascades, common cytokine receptor gamma-chain family signalling pathways and apoptotic pathways. Akt regulates proliferation, cell survival, growth, angiogenesis and tumor formation. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Akt1 and Akt2 are expressed in all human cell types and Akt 3 is highly expressed in brain, lung and kidney. Mutations in the AKT1 gene can result in breast cancer and colorectal cancer. STJ97726 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Akt protein which only binds about S473 when S473 is phosphorylated.
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