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Overview
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Bax is a protein encoded by the BAX gene which is approximately 21, 1 kDa. Bax is localised to the mitochondrion membrane and cytoplasm. It is involved in PEDF induced signalling, apoptosis modulation and signalling and the TNFR1 pathway. This protein falls under the BCL2 protein family. It forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein interacts with, and increases the opening of, the mitochondrial voltage-dependent anion channel, which leads to the loss in membrane potential and the release of cytochrome c. Bax is expressed in a wide variety of tissues. Mutations in the BAX gene may result in colorectal cancer and leukaemia. STJ91820 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bax protein.
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