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Overview
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This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
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- Properties
- Applications
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Overview
Immunofluorescence analysis of mouse colon using APC antibody (STJ22635) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of HT-29 cells using APC antibody (STJ22635) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human breast cancer using APC antibody (STJ22635) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human colon using APC antibody (STJ22635) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using APC antibody (STJ22635) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of HeLa cells, using APC antibody (STJ22635) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 90s.
Anti-APC antibody
Anti-APC antibody
Catalog Number:
A001033324STJ
Mfr. No.:
STJ22635
Price:
$297
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