Name: Anti-APEX1 antibody
Price: 295.00 USD

Overview
- Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1 (NP_542380. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Dna-(Apurinic Or Apyrimidinic Site Lyase; Apex Nuclease; Apen; Apurinic-Apyrimidinic Endonuclease 1; Ap Endonuclease 1; Ape-1; Ref-1; Redox Factor-1 Cleaved Into-Dna-(Apurinic Or Apyrimidinic Site Lyase-Mitochondrial (Gene ID:328; UniProt:P27695)
  
  * For research use only