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Overview
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alpha skeletal muscle actin is a protein encoded by the ACTA1 gene which is approximately 42 in kDa. alpha skeletal muscle actin is localised to the cytoplasm and cytoskeleton. It is involved in actin nucleation, the PAK pathway, VEGF pathway and Sertoli-Sertoli cell junction dynamics. This protein falls under the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus. alpha skeletal muscle actin is expressed in the muscle, heart, thyroid, liver and kidney. Mutations in the ACTA1 gene may result in zebra body myopathy. STJ97051 was developed from clone 4B11 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous alpha Skeletal Muscle Actin protein.
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