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Overview
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Transferrin is a protein encoded by the TF gene which is approximately 77 kDa. Transferrin is secreted into the extracellular space. It is involved in clathrin-mediated endocytosis, insulin receptor recycling, vesicle-mediated transport and ferroptosis. Its function is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. It may also have a physiologic role as a granulocyte and pollen-binding protein involved in the removal of certain organic matter and allergens from serum. Transferrin is expressed in the liver, nervous system, eye, heart and kidney. Mutations in the TF gene may result in iron metabolism disease. STJ97054 was developed from clone 7F4 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous Human Transferrin protein.
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