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Overview
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beta II tubulin is a protein encoded by the TUBB2A gene which is approximately 49, 9 kDa. beta II tubulin is localised to the cytoplasm and cytoskeleton. It is involved in Sertoli-Sertoli cell junction dynamics, development Slit-Robo signalling and the GPCR pathway. Tubulin is the major constituent of microtubules. Microtubules are key participants in processes such as mitosis and intracellular transport and are composed of heterodimers of alpha-and beta-tubulins. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. beta II tubulin is expressed in the nervous system, eye, skin and lung. Mutations in the TUBB2A gene may result in lung mucoepidermoid carcinoma. STJ97053 was developed from clone Mix and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous beta II tubulin protein.
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