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Overview
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This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.
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- Properties
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Overview
Immunofluorescence analysis of U-2 OS cells using AGR2 antibody (STJ29144) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of L929 cells using AGR2 antibody (STJ29144) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded Human lung cancer using AGR2 Rabbit pAb (STJ29144) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse lung using AGR2 Rabbit pAb (STJ29144) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using AGR2 antibody (STJ29144) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.
Anti-AGR2 antibody
Anti-AGR2 antibody
Catalog Number:
A001037170STJ
Mfr. No.:
STJ29144
Price:
$297
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