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Overview
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
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- Properties
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Overview
Immunofluorescence analysis of C6 cells using ABCB11 antibody (STJ116895) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of NIH/3T3 cells using ABCB11 antibody (STJ116895) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of rat liver, using ABCB11 antibody (STJ116895) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 1s.
Anti-ABCB11 antibody
Anti-ABCB11 antibody
Catalog Number:
A001023745STJ
Mfr. No.:
STJ116895
Price:
$297
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