Anti-IGF1R antibody

Catalog Number:

A001021560STJ

Mfr. No.:

STJ114609

Price:

$297

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Overview
- This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  A synthetic peptide of human IGF1R
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Insulin-Like Growth Factor 1 Receptor; Insulin-Like Growth Factor I Receptor; Igf-I Receptor; Cd Antigen Cd221 Cleaved Into-Insulin-Like Growth Factor 1 Receptor Alpha Chain-Insulin-Like Growth Factor 1 Receptor Beta Chain (Gene ID:3480; UniProt:P08069)
  
  * For research use only