Anidulafungin

- Overview
  - Anidulafungin is a semi-synthetic echinocandin derivative and antifungal effective against Candida spp. Anidulafungin inhibits fungal cell wall synthesis. It is useful in pharmacotherapy and cell culture research applications.
    Anidulafungin is slightly soluble in DMSO but practically insoluble in water.
    
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    Background
    
    Anidulafungin inhibits the enzyme (1→3)-β-D-glucan synthase, which is important in fungal cell wall synthesis. The enzyme is not found in mammalian systems.
- Properties
  - CAS Number
    
    166663-25-8
    
    Molecular Formula
    
    C58H73N7O17
    
    Molecular Weight
    
    1140.24
    
    Appearance
    
    White crystalline powder
    
    Solubility
    
    Slightly soluble in DMSO. Practically insoluble in water.
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤2.0%
    PH: 6.5 - 7.5
    Heavy Metals: ≤5ppm
    Identification: IR, HPLC - Passes test
    Purity Level: ≥98.0% (HPLC)
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Anidulafungin is active against Candida and Aspergillus spp.
    
    Eukaryotic Cell Culture Applications: Since the compound selectively targets fungal cells and does not exhibit cytotoxicity to mammalian cells in vitro (Harris and Coote, 2010), it is useful in cell culture to combat Candida and Aspergillus spp.