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Overview
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Background
Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem. Anhydrochlortetracycline showed a rather specific activity against actinomycetes. Preliminary data indicated that the compound showed no obvious toxicity to mice at doses of 160 mg/kg. Anhydrochlortetracycline showed a substantial in vitro activity against N. asteroides and S. salmonicida pathogens of man and fish, respectively [1].
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