Name: Luotonin F
Price: 369.00 USD

- Overview
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    Background
    
    Luotonin F is an alkaloid found in the aerial parts of the Peganum nigellastrum Bunge, a plant which has been long used in traditional Chinese medicine for the treatment of rheumatism, abscesses, and various other inflammatory conditions [1]. Due to their biological and pharmaceutical activities, many synthetic methods have been developed for the synthesis of luotonins. An efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin F from easily available starting materials. Through the rational logical design, multifundamental reactions were assembled in one-pot, such as iodination, Kornblum oxidation, and annulations [2]. The developed approach could efficiently synthesize luntonin F and various analogues. Luotonin F showed promising cytotoxicity against leukemia P-388 cells with an IC50 value of 2.3 μg/ml by stabilizing the DNA topoisomerase I-DNA complex [1].
    
    [1] Liang J L, Cha H C, Jahng Y. Recent advances in the studies on luotonins[J]. Molecules, 2011, 16(6): 4861-4883.
    [2] Zhu Y, Fei Z, Liu M, et al. Direct one-pot synthesis of Luotonin F and analogues via rational logical design[J]. Organic letters, 2012, 15(2): 378-381.
- Properties
  - Categories
    
    stabilizing the DNA topoisomerase I-DNA complex
    
    Alternative Name
    
    2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone
    
    CAS Number
    
    244616-85-1
    
    Molecular Formula
    
    C18H11N3O2
    
    Molecular Weight
    
    301.3
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤2.5mg/ml in DMSO;2.5mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1NC(C(C2=CC(C=CC=C3)=C3N=C2)=O)=NC4=CC=CC=C41
    
    * For Research Use Only