Name: Angiotensin 1/2 (1-9)
Price: 196.00 USD

- Overview
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    Background
    
    Angiotensin I/II (1-9) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS) containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.
    Angiotensin I is formed by the action of renin on angiotensinogen, which has 12 amino acids and is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin I. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzymeangiotensin-converting enzyme (ACE), primarily through ACE within the lung.
    Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron so that drives blood pressure up.
    
    1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.
    2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.
    3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.
- Properties
  - Categories
    
    Vasoconstrictor
    
    Alternative Name
    
    H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH; Angiotensin 1/2 (1-9)
    
    CAS Number
    
    34273-12-6
    
    Molecular Formula
    
    C56H78N16O13
    
    Molecular Weight
    
    1183.32
    
    Appearance
    
    A solid
    
    Purity
    
    98.77%
    
    Solubility
    
    ≥118.3 mg/mL in DMSO; insoluble in EtOH; ≥51 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
    
    * For Research Use Only