Myelopeptide-2 (MP-2)

- Overview
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    Background
    
    Myelopeptide-2 (MP-2) (C41H57N7O8), with the sequence Leu-Val-Val-Tyr-Pro-Trp, is originally isolated from the supernatant of porcine bone marrow cell culture, and is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from HL-60 leukemia cells or measles virus. The MP-2 recovery effect is connected with its influence on the CD3 and CD4 antigen expression on T lymphocytes. Research results also suggest that the MP-2 involvement in regulatory processes is directed to the maintenance of immune homeostasis. This peptide is perspective to be applied in antitumor and antivirus therapy.
    
    1. Mikhailova AA, Belevskaya RG, Kalyuzhnaya M, Fonina LA, Liashenko VA, Petrov RV. Myelopeptide-2 recovers interleukin-2 synthesis and interleukin-2 receptor expression in human T lymphocytes depressed by tumor products or measles virus.
- Properties
  - Categories
    
    Peptide used for restoring human T lymphocytes
    
    Alternative Name
    
    H2N-Leu-Val-Val-Tyr-Pro-Trp-OH
    
    Molecular Formula
    
    C41H57N7O8
    
    Molecular Weight
    
    775.93
    
    Appearance
    
    A solid
    
    Purity
    
    98.98%
    
    Solubility
    
    ≥77.5 mg/mL in DMSO; insoluble in H2O; ≥44.8 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    N[[email protected]@H](CC(C)C)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](CC1=CC=C(O)C=C1)C(N2[[email protected]@H](CCC2)C(N[[email protected]@H](CC3=CC(C=CC=C4)=C4N3)C(O)=O)=O)=O)=O)=O)=O
    
    * For Research Use Only