Name: ANP (1-11), rat
Price: 148.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Atrial Natriuretic Peptide (ANP) (C49H84N20O15S) has the sequence of H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH, is a 28 amino acid peptide that is synthesized, stored, and released by atrial myocytes in response to atrial distension, angiotensin II stimulation, endothelin, and sympathetic stimulation. ANP is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure.
    
    1. Widmaier, Eric P.; Hershel Raff, Kevin T. Strang (2008). Vander's Human Physiology, 11th Ed.. McGraw-Hill. pp. 291, 509–10.
    2. Marieb Human Anatomy & Physiology 9th edition, chapter:16, page:629, question number:14
    3. de Bold A (1985). "Atrial natriuretic factor: a hormone produced by the heart". Science 230 (4727): 767–70.
- Properties
  - Categories
    
    Vasodilator
    
    Alternative Name
    
    H2N-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH
    
    Molecular Formula
    
    C49H84N20O15S
    
    Molecular Weight
    
    1225.38
    
    Appearance
    
    A solid
    
    Purity
    
    95.92%
    
    Solubility
    
    ≥122.5 mg/mL in DMSO; insoluble in EtOH; ≥43.5 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    N[[email protected]@H](CO)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CO)C(N[[email protected]@H](CO)C(N[[email protected]@H](CS)C(N[[email protected]@H](CC1=CC=CC=C1)C(NCC(NCC(N[[email protected]@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
    
    * For Research Use Only
- Reference
  - 1. Zhijing Zhang, Lideng Guo, et al. "Adiponectin attenuates splenectomy-induced cognitive deficits by alleviating neuroinflammation and oxidative stress via the TLR4/MyD88/NF-κb signaling pathway in aged rats." Research Square.