Name: AGI-6780
Price: 258.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    AGI-6780 is a potent and selective inhibitor of tumor-associated IDH2/R140Q mutation with IC50 value of 23 nM [1].AGI-6780 could significantly reduce intracellular concentration of 2HG in the human glioblastoma TF1/R140Q cells, as well as reverse IDH2/R140Q-mediated differentiation block in TF1 cells in the presence of EPO. AGI-6780 could restore KLF1 and hemoglobin G1/2 expressions in the EPO-induced TF1/R140Q cells [1].
    
    [1] Wang F1, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, Straley K, Kernytsky A, Liu W, Gliser C, Yang H, Gross S, Artin E, Saada V,Mylonas E, Quivoron C, Popovici-Muller J, Saunders JO, Salituro FG, Yan S, Murray S, Wei W, Gao Y, Dang L, Dorsch M, Agresta S, Schenkein DP, Biller SA, Su SM, de Botton S, Yen KE. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013 May 3;340(6132):622-6.
- Properties
  - Alternative Name
    
    AGI 6780;AGI6780; 1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-ylphenyl]-3-[3-(trifluoromethyl)phenyl]urea
    
    CAS Number
    
    1432660-47-3
    
    Molecular Formula
    
    C21H18F3N3O3S2
    
    Molecular Weight
    
    481.51
    
    Appearance
    
    A solid
    
    Purity
    
    98.63%
    
    Solubility
    
    ≥22.25 mg/mL in DMSO; insoluble in H2O; ≥100.8 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

AGI-6780

AGI-6780

Background

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