Name: AIM-100
Price: 260.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    AIM-100 is a small inhibitor of Ack1 tyrosine kinase with IC50 value of 24 nM [1].
    AIM-100 mimicked ATP and inhibited the activity of Ack1 significantly and specifically. It showed no inhibition activity for the other 30 kinases including PI3-kinase and AKT, and showed a five-fold higher IC50 value for Lck. In MEF cells treated with EGF, AIM-100 caused a remarkable decrease of the activation of Ack1. In the human prostate cancer cells LNCaP and LAPC4, AIM-100 treatment resulted in an increase of G0/G1 cell phase and subsequent cell growth suppression. These effects of AIM-100 also exerted in the pancreatic cancer cells. AIM-100 induced apoptosis in Panc-1 cells at concentration of 10 μM. Moreover, AIM-100 inhibited cell growth with GI50 values of 7 to 8 μM in CD-18, Panc-1, OV90, MCF-7 and MDA-MB-468 cancer cells [1, 2].
    
    1. Mahajan K, Challa S, Coppola D, et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. The Prostate, 2010, 70(12): 1274-1285.
    2. Mahajan K, Coppola D, Chen Y, et al. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. The American journal of pathology, 2012, 180(4): 1386-1393.
- Properties
  - Alternative Name
    
    AIM 100;AIM100; N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
    
    CAS Number
    
    873305-35-2
    
    Molecular Formula
    
    C23H21N3O2
    
    Molecular Weight
    
    371.43
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Hongbing Jiang, Christian Leung, et al. "Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL and NCK1." bioRxiv. 2019 August 16.

AIM-100

AIM-100

Background

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