Name: AKT inhibitor VIII
Price: 277.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    AKT inhibitor VIII is a cell-permeable, reversible and potent, selective inhibitor of Akt1, Akt2 and Akt3 with IC50 values of 58 nM, 210 nM and 2.12 μM, respectively.
    AKT inhibitor VIII has shown to remarkably increase anti-proliferation induced by furanodiene in human breast cancer cell MCF-7. AKT inhibitor VIII could enhance the furanodiene- stimulated Akt and p-Akt expression decreases as well as increase furanodiene-induced PARP cleavage in MCF-7 cells [1].
    AKT inhibitor VIII has been revealed to inhibit IGF-1-induced Akt phosphorylation in a concentration-dependent manner. AKT inhibitor VIII has also been demonstrated to reduce PRAS40 phosphorylation in PC12 cells [2].
    
    [1] Zhong Z1, Dang Y, Yuan X, Guo W, Li Y, Tan W, Cui J, Lu J, Zhang Q, Chen X, Wang Y. Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. Cell Physiol Biochem. 2012;30(3):778-90.
    [2] Wang H1, Zhang Q, Zhang L, Little PJ, Xie X, Meng Q, Ren Y, Zhou L, Gao G, Quirion R, Zheng W. Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells. Neurosci Lett. 2012 May 10;516(1):105-9.
- Properties
  - Alternative Name
    
    3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one
    
    CAS Number
    
    612847-09-3
    
    Molecular Formula
    
    C34H29N7O
    
    Molecular Weight
    
    551.64
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥9.2 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Yingwei Xie, Zhiliang Chen, et al. "M2 Macrophages Secrete CXCL13 to Promote Renal Cell Carcinoma Migration, Invasion, and EMT." Cancer Cell Int. 2021 Dec 18;21(1):677. PMID:34922542
    2. Xiaowen Chen, Wenting Liu, et al. "FOXO3a accumulation and activation accelerate oxidative stress‐induced podocyte injury." FASEB J. 12 August 2020. PMID:32786113
    3. Eldad TZAHOR,Gabriele Matteo D'UVA,et al. "Methods, kits and devices for promoting cardiac regeneration." US Patent App. 15, 2016.
    4. D’Uva, Gabriele, et al. "ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation." Nature Cell Biology (2015). PMID:25848746

AKT inhibitor VIII

AKT inhibitor VIII

Background

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