Adrenomedullin (1-12), human

- Overview
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    Background
    
    Adrenomedullin (AM) (1-12), human (C64H100N22O19S1), is a peptide with the sequence Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg. It was first discovered to be associated with pheochromocytoma, a tumor arising from adrenal medulla, in 1993. AM was initially identified as a vasodilator, and as such, it has the ability to relax vascular tone. Previous research cited it as the most potent endogenous vasodilatory peptide found in the body. Other effects of AM include the increase of cell tolerance to oxidative stress and hypoxic injury and angiogenesis. AM is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular conditions.
- Properties
  - Categories
    
    Vasodilator
    
    Alternative Name
    
    H2N-Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-OH
    
    Molecular Formula
    
    C64H100N22O19S
    
    Molecular Weight
    
    1513.68
    
    Appearance
    
    A solid
    
    Purity
    
    98.99%
    
    Solubility
    
    insoluble in EtOH; ≥151.3 mg/mL in DMSO; ≥4.86 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    N[[email protected]@H](CC1=CC=C(O)C=C1)C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CCC(N)=O)C(N[[email protected]@H](CO)C(N[[email protected]@H](CCSC)C(N[[email protected]@H](CC(N)=O)C(N[[email protected]@H](CC(N)=O)C(N[[email protected]@H](CC2=CC=CC=C2)C(N[[email protected]@H](CCC(N)=O)C(NCC(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
    
    * For Research Use Only