Amyloid β-Protein (1-15)

- Overview
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    Background
    
    Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Research found that amyloid beta-protein circulates in human blood and in cerebrospinal fluid and is deposited into plaques found in the brains of patients with Alzheimer's disease (AD). The aggregation of the beta-amyloid protein into dense plaques on the exterior of brain cells results in destroys of the synapses and conduction of nerve impulses.
    
    1. Sisodia SS, Price DL. Role of the beta-amyloid protein in Alzheimer's disease. FASEB J. 1995 Mar; 9(5): 366-70.
- Properties
  - Categories
    
    Principal component of amyloid
    
    Alternative Name
    
    H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-OH
    
    CAS Number
    
    183745-81-5
    
    Molecular Formula
    
    C78H107N25O27
    
    Molecular Weight
    
    1826.86
    
    Appearance
    
    A solid
    
    Purity
    
    98.58%
    
    Solubility
    
    insoluble in EtOH; ≥182.6 mg/mL in DMSO; ≥50.7 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C)C(C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)N
    
    * For Research Use Only
- Reference
  - 1. Brendan J. Wall, Mark F. Will, et al. "Importance of Hydrogen Bonding: Structure–Activity Relationships of Ruthenium (III) Complexes with Pyridine-Based Ligands for Alzheimer's Disease Therapy." J Med Chem. 2021 Jul 22;64(14):10124-10138. PMID:34197109