ADC Control hIgG1-PBD Dimer

Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are sequence-selective DNA minor-groove binding agents that inhibit nucleic acid synthesis. PBD dimers, with two PBD units linked via their C8 positions, are more potent DNA alkylating agents than monomers and have been used by several companies to develop antibody-drug conjugates. This product is a control ADC for any IgG type antibody labeled with PBD dimers, particularly any ADC made using our Antibody or Protein PBD Dimer Conjugation Kit (Cat#: CM11439). The product uses a human IgG1 subtype antibody that does not bind to the target. It has an average of 2-4 PBD dimers loaded on each antibody and can be used for assessing the effect of PBD dimers alone (non-specific toxicity). The product uses a very low endotoxin level antibody as a starting material (≤0.5 EU/mg by the LAL method). The preparation and purification are conducted under a pyrogen free environment.

The final conjugate is lyophilized from pH 6.5 citrate buffer containing sugar-based stabilizer for easy shipping and storage.

The product is sold as 1 vial of 100 microgram (Cat# CM51104-100UG), 1 vial of 500 micrograms (Cat# CM51104-500UG), or 2 vials of 500 micrograms (Cat# CM51104-1MG).

Chemical Information
• Chemical name: ADC Control hIgG1-PBD Dimer
• Chemical formula: N/A
• Molecular weight: 152KDa
• CAS number: N/A

Antibody Information
• Immunogen: HEL (Hen Egg Lysozyme)
• Species Reactivity: chicken
• Expression Host: CHO-S cell line
• Class: Human IgG1, Kappa
• Antibody Type: Monoclonal
• Applications: ELISA, FACS, IF, IHC, in vivo studies, IP, WB
• Purification Method: Affinity purified

Drug Information
• Name: Mc-Val-Ala-PBD Dimer (Talirine, SGD-1910)
• CAS number: 1342820-51-2
• Chemical formula: C60H64N8O12
• MW: 1089.2
• Mechanism of action: Sequence-selective DNA minior-groove binding agents, inhibition of nucleic acid synthesis
• Activities: Antitumor

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