Actagardin

- Overview
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    Background
    
    Actagardin is a tetracyclic antibiotic. Actagardin is a tetracyclic antibiotic produced by several species of Actinoplanes. In vitro: During the repeated fermentations of actagardin, two new compounds, named D and E, were isolated. Compound D was found to be twice as active as actagardin against Streptococcus pyogenes C 203 and four times more active than actagardin against Staphylococcus aureus ATCC 6538, S. pneumoniae UC 41, and S. aureus TOUR in the in-vitro tests [1].In vivo: Animal study showed that compound D was also more effective than the parent compound actagardin against experimental infections in mice with either S. pyogenes C 203 or S. aureus TOUR, after sc administration. However, compound D was ineffective at doses up to 150 mg/kg when given orally to mice infected with S. pyogenes C 203. Moreover, compound D (LD50 1,250 mg/kg, mice, ip) was about 2.5 times more toxic than actagardine (3,310 mg/kg). In addition, compound E showed practically no in vitro activity up to 50 μg/ml against the tested organisms [1]. Clinical trial: So far, no clinical study has been conducted.
    
    [1] Malabarba A, Landi M, Pallanza R, Cavalleri B. Physico-chemical and biological properties of actagardine and some acid hydrolysis products. J Antibiot (Tokyo). 1985 Nov;38(11):1506-11.
- Properties
  - Categories
    
    tetracyclic antibiotic
    
    Alternative Name
    
    Antibiotic A 3802-IV-3,Gardimycin; D-cysteinyl-L-serylglycyl-L-tryptophyl-L-valyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-isoleucyl-L-a-glutamyl-L-cysteinylglycyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-valyl-L-isoleucyl-L-cysteinyl-L-alany
    
    CAS Number
    
    59165-34-3
    
    Molecular Formula
    
    C81H124N20O24S4
    
    Molecular Weight
    
    1890.2
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in ethanol;methanol;DMSO;dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C(CN1)N[[email protected]@H](CC2=CNC3=C2C=CC=C3)C(N[[email protected]@H](C(C)C)C(N[[email protected]](C(N[[email protected]]([[email protected]](C)SC[[email protected]](C(NCC(N[[email protected]@]([[email protected]@H]4C)([H])C(N[[email protected]@H](C(C)C)C(N[[email protected]@]5([H])[[email protected]@H](C)CC)=O)=O)=O)=O)([H])NC6=O)C(N[[email protected]@H](CC(C)C)C(N[[email protected]](C(N[[email protected]]([[email protected]@H](C)CC)([H])C(N[[email protected]]6CCC(O)=O)=O)=O)
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Actagardin

Background

Documents

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