Name: 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
Price: 244.00 USD

- Overview
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    Background
    
    2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is a nonpeptidic angiotensin II receptor antagonist.Angiotensin II is the critical pressor substance of the renin-angiotensin system (RAS). The angiotensin II system, a proteolytic cascade regulating hemodynamics and water and electrolyte balance, is able to contribute to hypertensive states in human. The effects of the octapeptide angiotensin I1 includs cardiac stimulation, vasoconstriction, stimulation of aldosterone synthesis and release, as well as renal reabsorption of sodium. In vitro: In a previous study, 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine was synthezed by reduction of 2-amino-3-nitropyridine derivatives to the corresponding diaminopyridine which was then condensed with an appropriate carboxylic acid in polyphosphoric acid. In vitro activity study showed that 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine was a nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold had been used to examine plenty of positional substitutions in the development of orally active, long duration antihypertensive agents [1].In vivo: Up to now, there is no animal in vivo data reported.Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Categories
    
    nonpeptidic angiotensin II receptor antagonist
    
    Alternative Name
    
    2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
    
    CAS Number
    
    133240-06-9
    
    Molecular Formula
    
    C10H13N3
    
    Molecular Weight
    
    175.2
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥45.7 mg/mL in EtOH; ≥5.3 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=CC(C)=C2C(N1)=NC(CC)=N2
    
    * For Research Use Only