Name: ABT-888 (Veliparib)
Price: 202.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    ABT-888, also named as Veliparib, is poly (ADP-ribose) polymerase (PARP) inhibitor and has demonstrated excellent in vivo efficacy in a broad spectrum of preclinical tumor models in combination with a variety of cytotoxic agents. PARP is involved in DNA repair and elevated PARP levels can result in resistance to cytotoxic chemotherapy and radiation. So, PARP inhibitors hold promise as chemotherapy and radiation sensitizers. ABT-888 is also active on microsatellite instability (MSI) cell lines harboring mutations in both MRE11 and RAD50 genes compared to microsatellite stable (MSS) cell lines (wild-type for both genes).
- Properties
  - Alternative Name
    
    ABT-888,ABT 888,ABT888,Veliparib; 1-[3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
    
    CAS Number
    
    912444-00-9
    
    Molecular Formula
    
    C13H16N4O
    
    Molecular Weight
    
    244.3
    
    Appearance
    
    A solid
    
    Purity
    
    99.54%
    
    Solubility
    
    insoluble in H2O; ≥10.6 mg/mL in EtOH with ultrasonic; ≥6.11 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Kouzoukas DE, Schreiber JA, et al. "PARP inhibition blocks alcohol-induced neurodegeneration and neuroinflammatory cytosolic phospholipase A2 elevations." Neurochem Int. 2019 Jun 25:104497. PMID:31251945
    2. Poh W, Dilley RL, et al. "BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloidb Malignancies." Clin Cancer Res. 2019 Jan 28. PMID:30692098
    3. Versano Z, Shany E, et al. "MutT homolog 1 counteracts the effect of anti-neoplastic treatments in adult and pediatric glioblastoma cells." Oncotarget. 2018 Jun 8;9(44):27547-27563. PMID:29938005
    4. Gao Y, Li C, et al. "SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming." Cancer Res. 2017 May 15;77(10):2674-2685. PMID:28416484
    5. Wang X, Sekine Y, et al."Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury." eNeuro. 2016 Dec 26;3(6). PMID:28032120
    6. Yalon M, Tuval-Kochen L, et al. "Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations." PLoS One. 2016 May 19;11(5):e0155711. PMID:27196668
    7. Nassour J, Martien S, et al."Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells." Nat Commun. 2016 Jan 29;7:10399. PMID:26822533