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Abiraterone acetate

Abiraterone acetate

Catalog Number:
L002369403APE
Mfr. No.:
APE-A8202
Price:
$145
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      • Overview

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          Background

          Abiraterone acetate is the 3β-acetate form of its active component abiraterone, a potent inhibitor of androgen biosynthesis. Abiraterone, a pregnenolone-derived 3-pyridyl steroidal compound, potently and irreversibly inhibits cytochrome P450 17 alpha-hydroxylase (CYP17), an important enzyme involved in the synthesis of androgen and cortisol, through a covalent binding mechanism with a value of 50% inhibition concentration IC50 of 72 nM, which is 10 to 30 times greater in potency, due to the 3-pyridyl substitution in its chemical structure, than the inhibition by ketoconazole. In order to improve the low solubility of abirateone, abiraterone acetate has been developed and used for the treatment of castration-resistant prostate cancer (CRPC).

      • Properties
        • Alternative Name
          [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
          CAS Number
          154229-18-2
          Molecular Formula
          C26H33NO2
          Molecular Weight
          391.55
          Appearance
          A solid
          Purity
          99.72%
          Solubility
          insoluble in H2O; ≥11.22 mg/mL in DMSO with gentle warming and ultrasonic; ≥15.7 mg/mL in EtOH
          Storage
          Store at -20°C

          * For Research Use Only

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