Name: Ritonavir
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Ritonavir, previously known as ABT-538, is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that exhibits potent in vitro inhibition against HIV-1 strain as well as HIV-2 strain with 50% effective concentration EC50 values of 0.022 μM and 0.16 μM respectively. Ritonavir binds to the HIV-1 protease inactivating its function to cleave the Gag and Gag-Pol polyproteins into the core proteins and viral enzymes, which results in the formation of noninfectious viral particles. X-ray crystallographic analysis reveals a hydrophobic cluster between the isopropyl substituent on the P3 thiazolyl group of ritonavir and the side chains of Pro-81 and Val-82 of HIV-1 protease within the complex of ritonavir/HIV-1 protease.
- Properties
  - Alternative Name
    
    Abbott 84538, ABT-538,Ritonavir; 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
    
    CAS Number
    
    155213-67-5
    
    Molecular Formula
    
    C37H48N6O5S2
    
    Molecular Weight
    
    720.9
    
    Appearance
    
    A solid
    
    Purity
    
    98.50%
    
    Solubility
    
    ≥26 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥9.02 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Ritonavir

Ritonavir

Background

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