6xHis-Ube2A (Rad6A)

- Overview
  - Ube2A is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. It shares 95% amino acid sequence identity with Ube2B. One function of Ube2A involves the formation of Ube2A/Rad18 (an E3 enzyme) complex to monoubiquitinate proliferating cell nuclear antigen (PCNA) thus activating it to repair DNA damage. Ube2A is an X – chromosomal gene. Mutations in Ube2A have been linked to intellectual disability (ID), severely impaired speech, amongst other symptoms.
    
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- Properties
  - Protein Name
    
    UBC2; HHR6A; MRXSN; RAD6A; MRXS30
    
    Source
    
    Bacterial recombinant
    
    Formulation
    
    20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
    
    Storage
    
    Store at -80°C; avoid multiple freeze-thaw cycles
    
    Concentration
    
    See tube label
    
    Molecular Weight
    
    17.1 kDa
    
    Sequence
    
    NCBI RefSeq: NM_003336
    
    * Research Use Only