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Overview
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6-Diazo-5-oxo-L-norleucine is a glutamine antagonist originally isolated from Streptomyces sp. 6-Diazo-5-oxo-L-norleucine has antitumor activity, disrupting the mitochondrial internal membrane structures of the neuroendocrine tumour cell line BON and causing DNA single-strand breaks. 6-Diazo-5-oxo-L-norleucine acts synergistically with L-asparaginase to inhibit U251, U87, and SF767 glioblastoma cells.
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Overview