Oxolinic Acid

- Overview
  - Oxolinic acid is a synthetic quinolone antibiotic. It is insoluble in water and soluble in dilute alkali solutions.
    
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    Background
    
    Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.
- Properties
  - CAS Number
    
    14698-29-4
    
    Molecular Formula
    
    C13H11NO5
    
    Molecular Weight
    
    261.23
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    Soluble in 0.5 N NaOH with heat as needed
    
    Other Properties
    
    Source: Synthetic
    Assay: (As Is): 98.0-102.0%
    Melting Point: 314-316°C
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Oxolinic acid targets gram-negative bacteria, especially those which cause urinary tract infections.
    
    Microbiology Applications: Oxolinic acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: Escherichia coli 0.06 µg/mL – 0.25 µg/mL Media Supplements Oxolinic acid can be used as a selective agent in several types of isolation media: Columbia Blood Agar - Streptococcus Selective Supplement (COBA)
    
    Plant Biology Applications: Oxolinic acid has proven to be effective against the seed-borne pathogen Burkholderia glumae which causes grain rot, sheath rot, seedling rot, and bacterial panicle blight. In an experiment performed by Ham et al., oxolinic acid was applied to plants infected by Burkholderia glumae. In the group treated with oxolinic acid, 97% of the plants were successfully treated in contrast to the 8% which survived the untreated control group.