5-Propynyl-2'-O-Methyl Cytidine CED phosphoramidite

5-Propynyl-2'-O-Methyl Cytidine CED phosphoramidite

Catalog Number:
NAS1056282CHE
Mfr. No.:
ANP-1874
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    • Overview

      • Please contact us at for specific academic pricing.

    • Properties
      • Categories
        Modified 2'-O-Methyl Amidites and Supports
        Molecular Formula
        C50H56N5O9P
        Molecular Weight
        901.980
        Shipping
        This material is sensitive to heat and moisture. It requires the fastest shipment possible.
    • Applications
      • Application Description
        2’-O-Methyl-5-propynyl-cytidine & 2’-O-Methyl-5-propynyl-uridine:

        The substitution of dC and dT in antisense phosphorothioate oligonucle­otides with C-5 propynyl group showed effective inhibition of gene expression. Both 2’-deoxy and 2’-OMe nucleo­tides incorporated into oligonucleotides have higher duplex stability com­pared to natural bases.1

        Reference:

        1. Wagner, R. W.; Matteucci, M. D.; Lewis, J. G.; Gutierrez, A. G.; Moulds, C.; Froeller, B. C. Science, 1993, 260, 1510.

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