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Overview
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5-Chloro-2-methyl-3-isothiazolone (CMIT) is a highly water-soluble apoptotic agent and preservative with numerous applications. It is used in anti-microbial coatings, latex formulations, hydraulic fracturing fluids, pesticides and cosmetics. CMIT in conjunction with 2-methyl-4-isothiazolin-3-one (MIT) is marketed as Kathon. CMIT is also an allergen. CMIT is active against gram-positive and gram-negative bacteria, yeasts and fungi. CMIT is believed to form mixed disulfides with protein thiol groups which then undergo thiol-disulfide exchange reactions to give mixed protein thiol disulfides leading to cell apoptosis and necrosis.
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- Properties
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Overview