Name: 3,4-Dideoxyglucosone-3-ene
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- Overview
  - 3,4-di-deoxyglucosone-3-ene is a bioreactive glucose degradation product which can be formed during heat sterilisation of glucose containing peritoneal dialysis solutions. Chemically, 3,4-Dideoxyglucosone-3-ene is an α,β-unsaturated carbonyl compound which increases its reactivity with cellular sulfhydryl, amino groups, proteins, and DNA. 3,4-Dideoxyglucosone-3-ene induces apoptosis in neutrophils, renal cells and peripheral blood mononuclear cells. Such induction leads to impaired peritoneal antibacterial defence.
    
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- Properties
  - Alternative Name
    
    3,4-DGE
    
    CAS Number
    
    252006-38-5
    
    Molecular Formula
    
    C6H8O4
    
    Molecular Weight
    
    144.13 g/mol
    
    MDL Number
    
    MFCD02683312
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ortiz et al (2006). 3,4-DGE is important for side effects in peritoneal dialysis what about its role in diabetes. Current Medicinal Chemistry. 13:2695-2702
    Catalan et al (2005). 3,4-Dideoxyglucosone-3-ene promotes leukocyte apoptosis. Kidney International. 68:1303-1311. Justo, Sanz et al (2005). 3,4-Dideoxyglucosone-3-ene induces apoptosis in renal tubular epithelial cells. Diabetes. 54:2424-2429.
    Justo, Sanz et al (2005). 3,4-Dideoxyglucosone-3-ene induces apoptosis in renal tubular epithelial cells. Diabetes. 54:2424-2429.