Name: SW203668
Price: 277.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    IC50: 0.022 μM for H2122 cellsSW203668 is a stearoyl CoA desaturase inhibitor.The enzyme of stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids such as palmitoleic acid and oleic acid, which are two most abundant monounsaturated fatty acids in human membranes, plasma lipids as well as adipose tissue. Though the endogenous synthesis of fatty acids in humans is not significant in most circumstances, it is increasingly becoming evident that SCD plays key structural and metabolic roles.In vitro: By the screening, the optimized benzothiazole SW203668 was found to be selectively toxic to various cell lines (IC50 = 0.022-0.116 μM). Moreover, the ectopic expression of CYP4F11 in H1155, an SW203668-insensitive cell line, led to its sensitization to toxicity by SW203668 and therefore these results confirmed that CYP4F11 could also activate SW203668 [1].In vivo: A PK analysis of SW203668 revealed that the plasma levels exceeded 0.3 μM for the first 6 h and a half-life of 8 h after an intraperitoneal injection at 25 mg/kg. Immunodeficient mice bear-ing 200 mm3 tumors derived either from H2122 cells (sensitive) or H1155 cells (insensitive) was intraperitoneally treated with 25 mg/kg of SW203668 twice a day for 10–15 d. Results showed that after administration of SW203668 a substantially reduced rate of growth in H2122-derived tumors was observed. While the H1155-derived tumors were unaffected, suggesting that the selectivity and cytotoxicity of SW203668 were maintained in vivo [1].Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide
    
    CAS Number
    
    1673556-40-5
    
    Molecular Formula
    
    C22H19N3O2S
    
    Molecular Weight
    
    389.5
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤20mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

SW203668

SW203668

Background

We Also Recommend

4-Quinolone-3-Carboxamide CB2 Ligand

ARN14974

JD5037