Name: Z-Endoxifen
Price: Inquiry

- Overview
  - Z-Endoxifen is the active metabolite of tamoxifen (FT32122, BT164438, FT27994) that acts as an inhibitor of the enzyme aromatase and as inhibitor of the binding of estradiol to estrogen receptors. As an antitumour agent, Z-endoxifen has shown that it has the potential to treat endocrine-resistant estrogen receptor-positive (ER+) breast cancers. Endoxifen is the most effective non-competitive inhibitor of aromatase by conferring molecular rigidity upon binding.
    
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- Properties
  - Categories
    
    Ligands of Nuclear Receptors
    
    CAS Number
    
    112093-28-4
    
    Molecular Formula
    
    C25H27NO2
    
    Molecular Weight
    
    373.49 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Jayaraman et al (2020). Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer. Breast Cancer Reseach 22: 51.
    Sgrignani et al (2014). Computational Approaches Elucidate the Allosteric Mechanism of Human Aromatase Inhibition: A Novel Possible Route to Small-Molecule Regulation of CYP450s Activities? Journal of Chemical Information and Modeling 54(10):2856–2868.