Name: (Z-Ala-Ala-Ala-Ala)2Rh110
Price: 323.00 USD

- Overview
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    Background
    
    (Z-Ala-Ala-Ala-Ala)2Rh110 is a fluorogenic elastase substrate.
    Elastase can break down elastin that is an elastic fibre that, together with collagen and can determine the mechanical properties of connective tissue. The neutrophil form breaks down the Outer membrane protein A of E. coli and other Gram-negative bacteria. In addition, elastase has the critical immunological role of breaking down Shigella virulence factors.
    In vitro: (Z-Ala-Ala-Ala-Ala)2Rh110 has been identified as a very sensitive fluorogenic elastase substrate. The colorless and nonfluorescent Z-Ala-Ala-Ala-Ala)2Rh110 was found to be selectively cleaved by elastase to yield the highly fluorescent compound rhodamine 110, which exhibited excellent spectral properties matching the optimal detection window of most fluorescence instruments. After cleavage, Abs(max) is at 497 nm and Em(max) is at 520 nm for rhodamine 110 [1].
    In vivo: Currently, there is no animal in vivo data reported.
    Clinical trial: So far, no clinical study has been conducted.
    
    Reference:[1] A. F. Johnson, M. D. Struthers, K. B. Pierson, et al. Nonisotopic DNA detection system employing elastase and a fluorogenic rhodamine substrate. Analytical Chemistry 65, 2352-2359 (1993).
- Properties
  - Categories
    
    fluorogenic elastase substrate
    
    Alternative Name
    
    (Z-Ala-Ala-Ala-Ala)2Rhodamine110|bis-(CBZ-L-alanyl-L-arginine amide) Rhodamine 110; N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-L-alanyl-N-[3-oxo-6’-[[N-[N-[N-[N-[(phenylmethoxy)carbonyl]-L-alanyl]-L-alanyl]-L-alanyl]-L-alanyl]amino]spiro[isobenzofuran-1(3H),9’-[9H
    
    CAS Number
    
    149695-85-2
    
    Molecular Formula
    
    C60H66N10O15
    
    Molecular Weight
    
    1167.2
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≤2mg/ml in DMSO;2mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C(O1)C2=CC=CC=C2C31C4=C(C=C(NC(C(C)NC(C(C)NC(C(C)NC(C(C)NC(OCC5=CC=CC=C5)=O)=O)=O)=O)=O)C=C4)OC6=C3C=CC(NC(C(C)NC(C(C)NC(C(C)NC(C(C)NC(OCC7=CC=CC=C7)=O)=O)=O)=O)=O)=C6
    
    * For Research Use Only