YAP-TEAD Inhibitor 1 (Peptide 17)

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    YAP-TEAD Inhibitor 1 (Peptide 17) is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). It has potential application value in YAP related cancer.
    
    Reference:
    [1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett, 2014, 5(9): 993-8.
- Properties
  - Alternative Name
    
    (S)-4-((S)-1-((S)-1-((S)-2-((3S,6S,9S,12R,18S,21S,24S,27S,30S,35aS)-18-((S)-2-((S)-1-((S)-2-acetamido-3-methylbutanoyl)pyrrolidine-2-carboxamido)-3-(3-chlorophenyl)propanamido)-27-(4-aminobutyl)-9-benzyl-30-butyl-24-(3-guanidinopropyl)-6-(hydroxymethyl)-2
    
    Molecular Formula
    
    C93H144ClN23O21S2
    
    Molecular Weight
    
    2019.86
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥24.45 mg/mL in DMSO; ≥47.6 mg/mL in EtOH; ≥89.4 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C([[email protected]](CCC1)N1C([[email protected]](CCCC)NC([[email protected]](CCCCN)NC([[email protected]](CCCNC(N)=N)NC([[email protected]](CC(C)C)NC([[email protected]@H](NC([[email protected]](CC2=CC(Cl)=CC=C2)NC([[email protected]]3N(C([[email protected]](C(C)C)NC(C)=O)=O)CCC3)=O)=O)CCSSC[[email protected]@H](C(N[[email protected]@H](CCCCN)C(N4[[email protected]@H](CCC4)C(N5[[email protected]@H](CCC5)C(N[[email protected]@H](CCC(O)=O)C(N)=O)=O)=O
    
    * For Research Use Only
- Reference
  - 1. Shuyi Chen, Huijie Wu, et al. "Loss of SPTBN1 suppresses autophagy via SETD7-mediated YAP methylation in hepatocellular carcinoma initiation and development." Cell Mol Gastroenterol Hepatol. 2021 Nov 2;S2352-345X(21)00234-4. PMID:34737104

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

YAP-TEAD Inhibitor 1 (Peptide 17)

YAP-TEAD Inhibitor 1 (Peptide 17)

Background

Documents

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