Name: Y-27632 dihydrochloride
Price: 236.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Y-27632 dihydrochloride is a small-molecule inhibitor of Rho-associated protein kinase p160ROCK with the IC50 of 140 nM. Y-27632 suppresses the kinase activity of both ROCK-1 and ROCK-2 in vitro, and this compound inhibits the kinases by binding to the catalytic site of ROCK-1 and ROCK-2. Thus Y-27632 function on Rho-mediated stress fiber formation, the G1-S phase progression and cytokinesis.
- Properties
  - Alternative Name
    
    y-27632, Y27632, Y-27632 dihydrochloride, Y 27632; 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
    
    CAS Number
    
    146986-50-7;129830-38-2
    
    Molecular Formula
    
    C14H21N3O·2HCl
    
    Molecular Weight
    
    320.26
    
    Appearance
    
    A solid
    
    Purity
    
    98.25%
    
    Solubility
    
    ≥111.2 mg/mL in DMSO; ≥17.57 mg/mL in EtOH; ≥52.9 mg/mL in H2O
    
    Storage
    
    Desiccate at 4°C or below
    
    * For Research Use Only
- Reference
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