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XMD17-109

XMD17-109

Catalog Number:
L002368935APE
Mfr. No.:
APE-A3942
Price:
$351
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      • Overview

        • Please contact us at for specific academic pricing.

          Background

          XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 μM, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 μM. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells.[1] Through intravenous injection and oral delivery of XMD17-109 in mice, the pharmacokinetic properties of this compound are as bellows: the T1/2 (half time) is 8.2 h, the plasma clearance is 8.64 mL/min/Kg (data of intravenous injection), the AUC (area under the curve) of oral delivery is 15745 h*ng/mL and the oral bioavailability is 90%.

      • Properties
        • Alternative Name
          XMD17 109
          CAS Number
          1435488-37-1
          Molecular Formula
          C36H46N8O3
          Molecular Weight
          638.8
          Appearance
          A solid
          Purity
          99.71%
          Solubility
          ≥31.95 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference

        • 1. Kristina Riege, Hajime Yurugi, et al. "ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression." Cell Death Dis. 2021 Oct 20;12(11):969. PMID:34671021

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