Name: WY-14643 (Pirinixic Acid)
Price: 188.00 USD

- Overview
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    Background
    
    WY-14643, also known as Pirinixic Acid, has an agonistic action as peroxisome proliferator-activated receptor (PPAR). It is shown that aliphatic α-substitution of WY-14643 enhances both PPARα and PPARγ agonism. It has been demonstrated that aliphatic substitution in a-position to the carboxylic acid head group of WY-14643 improves both PPARa and PPARg activity and leads to balanced dual PPARa/g agonists in the lower micromolar range, with a-hexyl pirinixic acid as the most active compound. WY-14,643 can moderately elevate the level of TNFa mRNA in the liver. WY-14,643 stimulates production of low levels of hepatic TNFα by Kupffer cells which acts indirectly as a hepatocyte mitogen.
- Properties
  - Categories
    
    PPARα agonist, selective and highly potent
    
    Alternative Name
    
    WY 14643,WY14643; 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanylacetic acid
    
    CAS Number
    
    50892-23-4
    
    Molecular Formula
    
    C14H14ClN3O2S
    
    Molecular Weight
    
    323.8
    
    Appearance
    
    A solid
    
    Purity
    
    99.71%
    
    Solubility
    
    insoluble in H2O; ≥16.2 mg/mL in DMSO; ≥48.8 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)SCC(=O)O)Cl)C
    
    * For Research Use Only
- Reference
  - 1. Tomoki Yagai, Tingting Yan, et al. "Feedback repression of PPARα signaling by Let-7 microRNA." Cell Rep. 2021 Aug 10;36(6):109506. PMID:34380035
    2. Weipeng Hu, Shan Jiang, et al. "High phosphate impairs arterial endothelial function through AMPK‐related pathways in mouse resistance arteries." Acta Physiologica.
    3. Bassem M. Shoucri, Eric S. Martinez, et al. "Retinoid X receptor activation alters the chromatin landscape to commit mesenchymal stem cells to the adipose lineage." Endocrinology. 2017 Jul.