Name: GW0742
Price: 204.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.
- Properties
  - Categories
    
    PPARδ/β agonist, potent and selective
    
    Alternative Name
    
    GW 0742; 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid
    
    CAS Number
    
    317318-84-6
    
    Molecular Formula
    
    C21H17F4NO3S2
    
    Molecular Weight
    
    471.49
    
    Appearance
    
    A solid
    
    Purity
    
    99.56%
    
    Solubility
    
    ≥47.1 mg/mL in DMSO; insoluble in H2O; ≥49.7 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC(=C(C=C3)C(F)(F)F)F)C)OCC(=O)O
    
    * For Research Use Only