Name: WS6
Price: 320.00 USD

- Overview
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    Background
    
    WS6 is a small-molecule inducer of β cell proliferation [1].
    β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin [1].
    WS6 is a small-molecule inducer of β cell proliferation. In mouse β cell line R7T1, WS6 induced cell proliferation with EC50 value of 0.28 µM. WS6 was very active in primary human and rodent islets. In primary rat and human β cells, WS6 induced rat β cell proliferation with EC50 value of 0.4 µM and increased 4% of rat β cells and 3% of human β cells to proliferate. In intact islet cultures, WS6 significantly induced proliferation [1]. In cultured human islets, WS6 induced β cell proliferation and also α cell proliferation. However, WS6 didn’t influence the expression of β cell-specific transcription factors and the amount of insulin-positive β cells, which suggested that WS6 didn’t influence β cell differentiation and human islet cell viability [2].
    In type 1 diabetes (T1D) mice, WS6 significantly reduced blood glucose and increased β cell proliferation from 3.8% to 6.4% [1].
    
    [1]. Shen W, Tremblay MS, Deshmukh VA, et al. Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening. J Am Chem Soc, 2013, 135(5): 1669-1672.
    [2]. Boerner BP, George NM, Mir SU, et al. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr J, 2015, 62(4): 379-386.
- Properties
  - Categories
    
    inducer of β cell proliferation
    
    Alternative Name
    
    N-[6-[4-[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide
    
    CAS Number
    
    1421227-53-3
    
    Molecular Formula
    
    C29H31F3N6O3
    
    Molecular Weight
    
    568.59
    
    Appearance
    
    A solid
    
    Purity
    
    99.12%
    
    Solubility
    
    insoluble in H2O; ≥11.52 mg/mL in EtOH; ≥15.95 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)CC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F
    
    * For Research Use Only