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UMI-77

UMI-77

Catalog Number:
I002097347UBP
Mfr. No.:
F7150
Price:
$260
  • Size:
    5 mg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • UMI-77 is a selective Mcl-1 inhibitor by binding of the BH3-binding groove of Mcl-1, by which it blocks the interactions of Bax/Mcl-1 and Bak/Mcl-1. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induces apoptosis of various pancreatic cancer cell lines.

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      • Properties
        • Protein Name
          2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid
          Source
          Synthetic
          Formulation
          C18H14BrNO5S2
          Storage
          Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light
          Molecular Weight
          468.34 g/mol

          * Research Use Only

    Datasheet
    MSDS

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