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Overview
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Selective formyl peptide receptor 2 (FPR2) antagonist.
WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signalling, which can inhibit WKYMVm binding to FPR2 with an C50 of 0.23 μM and can also inhibit intracellular calcium release induced by WKYMVm, MMK 1, amyloid 42, and F peptide. WRW4 inhibits FPR2-mediated signalling in human neutrophils and blocks chemotactic migration and superoxide generation by amyloid 42 peptide. WRW4 can reduce Brucella proliferation in animal models.
Please contact us for availability.Please contact us at for specific academic pricing.
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