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Overview
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WEB 2086 (apafant) is a potent and selective platelet activating (PAF) antagonist. WEB 2086 has high affinity for guinea pig peritoneal macrophage PAF receptors, dissociating slowly. WEB 2086 at 10-8 to 10-6 mol/L strongly and concentration-dependently inhibits PAF-induced chemotaxis in guinea pig eosinophils. In animal models, WEB 2086 (0.1% w/v) blocks eosinophil activation in allergic conjunctivitis and inhibits the hypotensive and lethal effect of PAF in the rat in a dose-related manner.
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