Name: Ursodiol
Price: 180.00 USD

- Overview
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    Background
    
    Ursodiol (Ursodeoxycholic acid) is bile acids used in treatment of primary biliary cirrhomized (PBC) [1].Ursodiol (Ursodeoxycholic acid) has been reported to prevent progression of PBC, and increase survival. In addition, Ursodiol has been revealed to inhibit the initiation and postinitiation phases of azoxymethane-induced colonic tumor development. Moreover, Ursodiol has been noted to dose-dependently inhibit the viability of HepG2 and BEL7402 cell lines with IC50 values of 0.92mmol/L and 0.86mmol/L, respectively. Ursodiol has also reported to dose-dependently and significantly enhance the apoptosis rates in HepG2 and BEL7402 cells. Besides, treatment of Ursodiol has shown the reduction of the ecpression of cell cycle regulating proteins (cyclinD1,cyclin D3, Cdk2 and Cdk4) in Western blot analysis [1].
    
    [1] Liu H1, Qin CY, Han GQ, Xu HW, Meng M, Yang Z. Mechanism of apoptotic effects induced selectively by ursodeoxycholic acid on human hepatoma cell lines. World J Gastroenterol. 2007 Mar 21;13(11):1652-8.
- Properties
  - Categories
    
    Bile acids for PBC treatment
    
    Alternative Name
    
    (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
    
    CAS Number
    
    128-13-2
    
    Molecular Formula
    
    C24H40O4
    
    Molecular Weight
    
    392.57
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥16 mg/mL in DMSO; ≥50.5 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]]1C[[email protected]](C[[email protected]](O)[[email protected]]2([H])[[email protected]]3([H])CC[[email protected]@]4(C)[[email protected]@]2([H])CC[[email protected]]4([H])[[email protected]](C)CCC(O)=O)([H])[[email protected]]3(C)CC1
    
    * For Research Use Only