TW-37

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    TW-37 is a potent small-molecule inhibitor of BCL-2 (Ki = 290 nmol/L), which attenuates BCL-2 activation and inhibits multiple BCL-2 family members including BCL-XL (Ki = 1,110 nmol/L) and MCL-1 (Ki = 260 nmol/L). It binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2 preventing the heterodimerization of proapoptotic proteins (such as Bid, Bim, and Bad) with BCL-2 and subsequently allowing them to induce apoptosis. Recent studies indicate TW-37 is able to inhibit the growth of a broad range of cancer cells (such as breast, prostate, lymphoma, and pancreatic cancer), since it induces S-phase cell cycle arrest with regulation of several important cell cycle related genes, including p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1 and cyclin E.
- Properties
  - Alternative Name
    
    TW37,TW 37; N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
    
    CAS Number
    
    877877-35-5
    
    Molecular Formula
    
    C33H35NO6S
    
    Molecular Weight
    
    573.7
    
    Purity
    
    99.12%
    
    Solubility
    
    insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. In-Hyoung Yang, Seung-Hyun Hong, et al. "Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3–Mcl-1 signaling." Cancer Cell Int 2020 Aug 26;20:405. PMID:32863764
    2. Chi-Hyun Ahn, Won Woo Lee, et al. "Antitumor effect of TW-37, a BH3 mimetic in human oral cancer." Laboratory Animal Research. 04 December 2019.
    3. Villalobos-Ortiz M, Ryan J, et al. "BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics." Cell Death Differ. 2019 Jul 22. PMID:31332296
    4. Yang IH, Ahn CH, et al. "Heme Oxygenase-1 is a Key Molecule Underlying Differential Response of TW-37-Induced Apoptosis in Human Mucoepidermoid Carcinoma Cells." Molecules. 2019 May 1;24(9). pii: E1700. PMID:31052354
    5. Russo M, Milito A, et al. "CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia." Oncotarget. 2017 Jun 27;8(26):42571-42587. PMID:28489572

TW-37

Background

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