Name: Trichostatin A (TSA)
Price: 392.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Trichostatin A (TSA) is a potent inhibitor of histone deacetylase (HDAC) as well as an antifungal antibiotic with cytostatic and differentiating properties that noncompetivively and reversibly inhibits HDAC, at low nanomolar concentrations, in both cultured mammalian cells and fractionated cell nuclear extracts. It is capable of arresting cells in G1 and G2 phases of the cell cycle, inducing differentiation and reverting the transformed morphology of cells in culture. According to a study investigating the effect of TSA in human breast cancer cell lines, TSA inhibited proliferation of breast carcinoma cell lines (IC50 124.4 ± 120.4 nM), comparing to all cell lines (IC50 2.4 ± 0.5 nM), and resulted in pronounced histone H4 hyperacetylation.
- Properties
  - Alternative Name
    
    Trichostatin A,TSA; (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
    
    CAS Number
    
    58880-19-6
    
    Molecular Formula
    
    C17H22N2O3
    
    Molecular Weight
    
    302.37
    
    Purity
    
    96.80%
    
    Solubility
    
    insoluble in H2O; ≥15.12 mg/mL in DMSO; ≥16.56 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Desiccate at -20°C
    
    * For Research Use Only
- Reference
  - 1. Jan Zimak, Zachary W Wagoner, et al. "Epigenetic silencing directs expression heterogeneity of stably integrated multi-transcript unit genetic circuits." Sci Rep. 2021 Jan 28;11(1):2424. PMID:33510302
    2. Tianliang Li, Ligang Kong, et al. "Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit lc3-associated phagocytosis as a survival strategy." Nat Microbiol. 2021 Mar;6(3):366-379. PMID:33462436
    3. Somayeh Layeghi-Ghalehsoukhteh, Shreoshi Pal Choudhuri, et al. "Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics." Sci Rep. 2020 Nov 26;10(1):20662. PMID:33244070
    4. Haiyang Yu, Shan Lu, et al. "TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli." bioRxiv. March 29, 2020.
    5. Xu W, Huang M, et al. "The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer." Int J Biol Sci. 2020;16(8):1388-1402. PMID:32210727
    6. Tang Y, Yu W. "SIRT1 and p300/CBP regulate the reversible acetylation of serine-threonine kinase NDR2." Biochem Biophys Res Commun. 2019 Aug 16. pii: S0006-291X(19)31586-4. PMID:31427083
    7. Dhana Friedrich, Laura Friedel, et al. "Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency." bioRxiv. 2019 June 21.
    8. Wang MH, Wu CH, et al. "Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls." Dev Biol. 2019 May 15;449(2):122-131. PMID:30826398
    9. Zheng Q, Liu P, et al. "Mitochondrion-processed TERC regulates senescence without affecting telomerase activities." Protein Cell. 2019 Feb 20. PMID:30788732
    10. Deng R, Zhang P, et al. "HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer." Clin Epigenetics. 2018 Dec 11;10(1):153. PMID:30537988
    11. Ling H, Peng L, et al. "Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication." Cell Rep. 2018 Dec 4;25(10):2851-2865.e3. PMID:30517871
    12. Jiang H, Zhang S, et al. "Trichostatin a Protects Dendritic Cells Against Oxygen-Glucose Deprivation via the SRSF3/PKM2/Glycolytic Pathway." Front Pharmacol. 2018 Jun 11;9:612. PMID:29942258
    13. Prasad H, Rao R. "Histone deacetylase-mediated regulation of endolysosomal pH." J Biol Chem. 2018 Mar 22. pii: jbc.RA118.002025. PMID:29567836
    14. Choi S, Uehara H, et al. "RNA activating-double stranded RNA targeting flt-1 promoter inhibits endothelial cell proliferation through soluble FLT-1 upregulation." PLoS One. 2018 Mar 6;13(3):e0193590. PMID:29509796
    15. Rajini Rao, Hari Prasad. "A conserved mechanism for regulation of endo-lysosomal pH by histone deacetylases." bioRxiv. 2018 January 22.
    16. Hari Prasad, Rajini Rao. "The Amyloid Clearance Defect in ApoE4 Astrocytes is Corrected by Epigenetic Restoration of NHE6." bioRxiv. 2018.January. 4
    17. Yan Y, Wang H, et al. "HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila." Dev Cell. 2017 Oct 9;43(1):99-111.e5. PMID:28966044
    18. Hai Y, Shinsky SA, et al. "Histone deacetylase 10 structure and molecular function as a polyamine deacetylase." Nat Commun. 2017 May 18;8:15368. PMID:28516954
    19. Mitani Y, Vagnozzi RJ, Millay DP. "In vivo myomaker-mediated heterologous fusion and nuclear reprogramming. FASEB J. 2017 Jan;31(1):400-411." PMID:27825107
    20. Cai D, Wang X, et al. "Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators." Antiviral Res. 2016 May 13;132:26-37. PMID:27185623

Trichostatin A (TSA)

Trichostatin A (TSA)

Background

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