Name: SR 11302
Price: 352.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    SR 11302 is an inhibitor of activator protein-1 (AP-1) [1].AP-1 is a transcription factor that displays antitumor effects in vivo. SR 11302 is an inhibitor of AP-1 but don’t activate RARs and RXR. SR11302 failed to inhibit the proliferation of F9 cells, the embryonal carcinoma cell line. While, it can inhibit the growth of breast cancer cell line T-47D, the lung cancer line Calu-6 and HeLa cells[1]. SR 11302 had very little effect on either the proliferation or the differentiation of HL-60, fresh APL and NB4 cells, which indicate that AP-1 may not be involved in the signaling pathway of proliferation and differentiation of HL-60, fresh APL and NB4 cells [2].In an AP-1-luciferase transgenic mouse carcinogenesis model, SR11302 significantly inhibit both AP-1 activation in 7,12-dimethyl benz(a)anthracene-initiated mouse skin and 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation. While, SR11235, a retinoid with RARE transactivating activity, but lack of AP-1 inhibiting effect, didn’t inhibit papilloma formation and AP-1 activation. These results show that the antitumor effect of retinoids is mediated by blocking AP-1 activity in vivo [3].
    
    [1]. Fanjul A, Dawson MI, Hobbs PD, et al. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature, 1994, 372(6501): 107-111.
    [2]. Shiohara M, Dawson MI, Hobbs PD, et al. Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood, 1999, 93(6): 2057-2066.
    [3]. Huang C, Ma WY, Dawson MI, et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci U S A, 1997, 94(11): 5826-5830.
- Properties
  - Alternative Name
    
    3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
    
    CAS Number
    
    160162-42-5
    
    Molecular Formula
    
    C26H32O2
    
    Molecular Weight
    
    376.54
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥ 95.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Lingyu Wang, Zizhen Gong, et al. "Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation." Gut Microbes. 2020 Nov 9;12(1):1-20. PMID:33006494
    2. Weiler J, Dittmar T. "Minocycline impairs TNF-α-induced cell fusion of M13SV1-Cre cells with MDA-MB-435-pFDR1 cells by suppressing NF-κB transcriptional activity and its induction of target-gene expression of fusion-relevant factors." Cell Commun Signal. 2019 Jul 2;17(1):71. PMID:31266502
    3. Ding RR, Yuan JL, et al. "Epstein-Barr virus-encoded LMP1 regulated Pim1 kinase expression promotes nasopharyngeal carcinoma cells proliferation." Onco Targets Ther. 2019 Feb 11;12:1137-1146. PMID:30809095
    4. Wang T, Jin X, et al."Association of NF-κB and AP-1 with MMP-9 Overexpression in 2-Chloroethanol Exposed Rat Astrocytes." Cells. 2018 Aug 7;7(8). pii: E96. PMID:30087244
    5. Michael John Vanden Oever. "Regulation of Type VII Collagen in Patients with Recessive Dystrophic Epidermolysis Bullosa." UNIVERSITY OF MINNESOTA.2017.

SR 11302

SR 11302

Background

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